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Identifying Autism Susceptibility Genes

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Dec 20, 2004
Applications Due:

Apr 19, 2005

total funding: $4,295,000
max award: none
min award: none
cost sharing, matching: No
number of awards: 2
type of funding: Grant
Description:

The goal of this Request for Applications (RFA) is to solicit applications to identify specific genes and gene variants in localized chromosomal regions that confer susceptibility to autism. Fine mapping of disease loci, or quantitative trait loci (QTLs), is expected to occur in very large datasets of pre-existing samples that have high statistical power for fine mapping autism susceptibility loci. In order to improve the probability of obtaining biologically and clinically meaningful associations between genotypes and disease outcomes, this initiative will not be limited to fine-scale mapping of a disease locus but will proceed to the next level of positional identification of strong candidate genes via assessment of the functional significance of the autism - associated genetic variants. Such assessments should include approaches based on computational biology, comparative and evolutionary genomics, as well as experimental evidence from relevant in v!
itro or animal model studies designed to probe the effect of genetic variants on gene expression, splicing or function.Applications are encouraged to focus on complex modes of inheritance that include multiple risk factors, e.g., environmental, multigenic and epigenetic effects. New data collection activities will not be supported. Data - and biomaterials, if possible - analyzed in projects supported under this RFA can be included in a data management and cell repository facility maintained under the NIMH Human Genetics Initiative (http://nimhgenetics.org) and broadly distributed to the scientific community.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Individual/Family
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Biological Response to Environmental Health Hazards
Extramural Research Programs in the Neurosciences and Neurological Disorders
Mental Health Research Grants
National Institute of Child Health and Human Development Extramural Research
Research Related to Deafness and Communication Disorders

More Information:

http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-05-007.html

If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

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